Evidence for “What is nerve transfer surgery?” is based on:
Ahuja, C. S., Wilson, J. R., Nori, S., Kotter, M. R. N., Druschel, C., Curt, A., & Fehlings, M. G. (2017). Traumatic spinal cord injury. Nature Reviews Disease Primers, 3(1), 17018. https://doi.org/10.1038/nrdp.2017.18
Hill, E. J. R., & Fox, I. K. (2019). Current Best Peripheral Nerve Transfers for Spinal Cord Injury. Plastic & Reconstructive Surgery, 143(1), 184e–198e. https://doi.org/10.1097/PRS.0000000000005173
Evidence for “What can nerve transfers help with?” is based on:
Mahar, M., & Cavalli, V. (2018). Intrinsic mechanisms of neuronal axon regeneration. Nature Reviews Neuroscience, 19(6), 323–337. https://doi.org/10.1038/s41583-018-0001-8
Bazarek, S., & Brown, J. M. (2020). The evolution of nerve transfers for spinal cord injury. Experimental Neurology, 333, 113426. https://doi.org/10.1016/j.expneurol.2020.113426
Bunketorp-Käll, L., Reinholdt, C., Fridén, J., & Wangdell, J. (2017). Essential gains and health after upper-limb tetraplegia surgery identified by the International classification of functioning, disability and health (ICF). Spinal Cord, 55(9), 857–863. https://doi.org/10.1038/sc.2017.36
Evidence for Table 1 is based on:
Bazarek, S., & Brown, J. M. (2020). The evolution of nerve transfers for spinal cord injury. Experimental Neurology, 333, 113426. https://doi.org/10.1016/j.expneurol.2020.113426
Galea, M., Messina, A., Hill, B., Cooper, C., Hahn, J., & van Zyl, N. (2020). Reanimating hand function after spinal cord injury using nerve transfer surgery. Advances in Clinical Neuroscience & Rehabilitation, 20(2), 17–19. https://doi.org/10.47795/CQZF2655
Evidence for “Who is suitable for a nerve transfer?” is based on:
Khalifeh, J. M., Dibble, C. F., Van Voorhis, A., Doering, M., Boyer, M. I., Mahan, M. A., Wilson, T. J., Midha, R., Yang, L. J. S., & Ray, W. Z. (2019a). Nerve transfers in the upper extremity following cervical spinal cord injury. Part 1: Systematic review of the literature. Journal of Neurosurgery: Spine, 31(5), 629–640. https://doi.org/10.3171/2019.4.SPINE19173
Dengler, J., Mehra, M., Steeves, J. D., Fox, I. K., Curt, A., Maier, D., Abel, R., Weidner, N., Rupp, R., Vidal, J., Benito, J., Kalke, Y.-B., Curtin, C., Kennedy, C., Miller, A., Novak, C., Ota, D., & Stenson, K. C. (2021). Evaluation of Functional Independence in Cervical Spinal Cord Injury: Implications for Surgery to Restore Upper Limb Function. The Journal of Hand Surgery, 46(7), 621.e1-621.e17. https://doi.org/10.1016/j.jhsa.2020.10.036
Kirshblum, S. C., Burns, S. P., Biering-Sorensen, F., Donovan, W., Graves, D. E., Jha, A., Johansen, M., Jones, L., Krassioukov, A., Mulcahey, M. J., Schmidt-Read, M., & Waring, W. (2011). International standards for neurological classification of spinal cord injury (Revised 2011). The Journal of Spinal Cord Medicine, 34(6), 535–546. https://doi.org/10.1179/204577211X13207446293695
Javeed, S., Dibble, C. F., Greenberg, J. K., Zhang, J. K., Khalifeh, J. M., Park, Y., Wilson, T. J., Zager, E. L., Faraji, A. H., Mahan, M. A., Yang, L. J., Midha, R., Juknis, N., & Ray, W. Z. (2022). Upper Limb Nerve Transfer Surgery in Patients With Tetraplegia. JAMA Netw Open, 5(11), e2243890-. https://doi.org/10.1001/jamanetworkopen.2022.43890
Khalifeh, J. M., Dibble, C. F., Van Voorhis, A., Doering, M., Boyer, M. I., Mahan, M. A., Wilson, T. J., Midha, R., Yang, L. J. S., & Ray, W. Z. (2019b). Nerve transfers in the upper extremity following cervical spinal cord injury. Part 2: Preliminary results of a prospective clinical trial. Journal of Neurosurgery: Spine, 31(5). https://doi.org/10.3171/2019.4.SPINE19399
van Zyl, N., Hill, B., Cooper, C., Hahn, J., & Galea, M. P. (2019). Expanding traditional tendon-based techniques with nerve transfers for the restoration of upper limb function in tetraplegia: a prospective case series. Lancet, 394(10198), 565–575. https://doi.org/10.1016/S0140-6736(19)31143-2
Stanley, E. A., Hill, B., McKenzie, D. P., Chapuis, P., Galea, M. P., & N, van Z. (2022). Predicting strength outcomes for upper limb nerve transfer surgery in tetraplegia. J Hand Surg Eur Vol, 47(11), 1114–1120. https://doi.org/10.1177/17531934221113739
Berger, M. J., Dengler, J., Westman, A., Curt, A., Schubert, M., Abel, R., Weidner, N., Röhrich, F., & Fox, I. K. (2023). Nerve transfer after cervical spinal cord injury: Who has a “time sensitive” injury based on electrodiagnostic findings? Archives of Physical Medicine and Rehabilitation. https://doi.org/10.1016/j.apmr.2023.11.003
Bryden, A. M., Hoyen, H. A., Keith, M. W., Mejia, M., Kilgore, K. L., & Nemunaitis, G. A. (2016). Upper Extremity Assessment in Tetraplegia: The Importance of Differentiating Between Upper and Lower Motor Neuron Paralysis. Archives of Physical Medicine and Rehabilitation, 97(6), S97–S104. https://doi.org/10.1016/j.apmr.2015.11.021
Castanov, V., Berger, M., Ritsma, B., Trier, J., & Hendry, J. M. (2021). Optimizing the Timing of Peripheral Nerve Transfers for Functional Re-Animation in Cervical Spinal Cord Injury: A Conceptual Framework. Journal of Neurotrauma, 38(24), 3365–3375. https://doi.org/10.1089/neu.2021.0247
Hill, E. J. R., & Fox, I. K. (2019). Current Best Peripheral Nerve Transfers for Spinal Cord Injury. Plastic & Reconstructive Surgery, 143(1), 184e–198e. https://doi.org/10.1097/PRS.0000000000005173
Jain, N. S., Hill, E. J. R., Zaidman, C. M., Novak, C. B., Hunter, D. A., Juknis, N., Ruvinskaya, R., Kennedy, C. R., Vetter, J., Mackinnon, S. E., & Fox, I. K. (2020). Evaluation for Late Nerve Transfer Surgery in Spinal Cord Injury: Predicting the Degree of Lower Motor Neuron Injury. J Hand Surg Am, 45(2), 95–103. https://doi.org/10.1016/j.jhsa.2019.11.003
Fox, I. K., Novak, C. B., Krauss, E. M., Hoben, G. M., Zaidman, C. M., Ruvinskaya, R., Juknis, N., Winter, A. C., & Mackinnon, S. E. (2018). The Use of Nerve Transfers to Restore Upper Extremity Function in Cervical Spinal Cord Injury. PM&R, 10(11), 1173. https://doi.org/10.1016/j.pmrj.2018.03.013
Evidence for “What is the process for a nerve transfer?” is based on:
Dengler, J., Steeves, J. D., Curt, A., Mehra, M., Novak, C. B., & Fox, I. K. (2022). Spontaneous Motor Recovery after Cervical Spinal Cord Injury: Issues for Nerve Transfer Surgery Decision Making. Spinal Cord, 60(10), 922–927. https://doi.org/10.1038/s41393-022-00834-6
Hill, E. J. R., & Fox, I. K. (2019). Current Best Peripheral Nerve Transfers for Spinal Cord Injury. Plastic & Reconstructive Surgery, 143(1), 184e–198e. https://doi.org/10.1097/PRS.0000000000005173
Kane, N. M., & Oware, A. (2012). Nerve conduction and electromyography studies. Journal of Neurology, 259(7), 1502–1508. https://doi.org/10.1007/s00415-012-6497-3
Berger, M. J., Dengler, J., Westman, A., Curt, A., Schubert, M., Abel, R., Weidner, N., Röhrich, F., & Fox, I. K. (2023). Nerve transfer after cervical spinal cord injury: Who has a “time sensitive” injury based on electrodiagnostic findings? Archives of Physical Medicine and Rehabilitation. https://doi.org/10.1016/j.apmr.2023.11.003
Bersch, I., & Fridén, J. (2020). Upper and lower motor neuron lesions in tetraplegia: implications for surgical nerve transfer to restore hand function. J Appl Physiol (1985), 129(5), 1214–1219. https://doi.org/10.1152/japplphysiol.00529.2020
van Zyl, N., Hill, B., Cooper, C., Hahn, J., & Galea, M. P. (2019). Expanding traditional tendon-based techniques with nerve transfers for the restoration of upper limb function in tetraplegia: a prospective case series. Lancet, 394(10198), 565–575. https://doi.org/10.1016/S0140-6736(19)31143-2
Fox, I. K., Miller, A. K., & Curtin, C. M. (2018). Nerve and Tendon Transfer Surgery in Cervical Spinal Cord Injury: Individualized Choices to Optimize Function. Topics in Spinal Cord Injury Rehabilitation, 24(3), 275–287. https://doi.org/10.1310/sci2403-275
Kahn, L. C., Evans, A. G., Hill, E. J. R., & Fox, I. K. (2022). Donor activation focused rehabilitation approach to hand closing nerve transfer surgery in individuals with cervical level spinal cord injury. Spinal Cord Ser Cases, 8(1), 47. https://doi.org/10.1038/s41394-022-00512-y
Aguirre-Güemez, A. V, Mendoza-Muñoz, M., Jiménez-Coello, G., Rhoades-Torres, G. M., Pérez-Zavala, R., Barrera-Ortíz, A., & Quinzaños-Fresnedo, J. (2021). Nerve transfer rehabilitation in tetraplegia: Comprehensive assessment and treatment program to improve upper extremity function before and after nerve transfer surgery, a case report. J Spinal Cord Med, 44(4), 621–626. https://doi.org/10.1080/10790268.2019.1660841
Javeed, S., Dibble, C. F., Greenberg, J. K., Zhang, J. K., Khalifeh, J. M., Park, Y., Wilson, T. J., Zager, E. L., Faraji, A. H., Mahan, M. A., Yang, L. J., Midha, R., Juknis, N., & Ray, W. Z. (2022). Upper Limb Nerve Transfer Surgery in Patients With Tetraplegia. JAMA Netw Open, 5(11), e2243890-. https://doi.org/10.1001/jamanetworkopen.2022.43890
Larocerie-Salgado, J., Chinchalkar, S., Ross, D. C., Gillis, J., Doherty, C. D., & Miller, T. A. (2022). Rehabilitation Following Nerve Transfer Surgery. Techniques in Hand & Upper Extremity Surgery, 26(2), 71–77. https://doi.org/10.1097/BTH.0000000000000359
Opsommer, E., Chevalley, O., & Korogod, N. (2020). Motor imagery for pain and motor function after spinal cord injury: a systematic review. Spinal Cord, 58(3), 262–274. https://doi.org/10.1038/s41393-019-0390-1
Evidence for “How do nerve transfers compare to tendon transfers?” is based on:
Bazarek, S., & Brown, J. M. (2020). The evolution of nerve transfers for spinal cord injury. Experimental Neurology, 333, 113426. https://doi.org/10.1016/j.expneurol.2020.113426
van Zyl, N., Hill, B., Cooper, C., Hahn, J., & Galea, M. P. (2019). Expanding traditional tendon-based techniques with nerve transfers for the restoration of upper limb function in tetraplegia: a prospective case series. Lancet, 394(10198), 565–575. https://doi.org/10.1016/S0140-6736(19)31143-2
Evidence for Table 2 is based on:
van Zyl, N., Hill, B., Cooper, C., Hahn, J., & Galea, M. P. (2019). Expanding traditional tendon-based techniques with nerve transfers for the restoration of upper limb function in tetraplegia: a prospective case series. Lancet, 394(10198), 565–575. https://doi.org/10.1016/S0140-6736(19)31143-2
Aguirre-Güemez, A. V, Mendoza-Muñoz, M., Jiménez-Coello, G., Rhoades-Torres, G. M., Pérez-Zavala, R., Barrera-Ortíz, A., & Quinzaños-Fresnedo, J. (2021). Nerve transfer rehabilitation in tetraplegia: Comprehensive assessment and treatment program to improve upper extremity function before and after nerve transfer surgery, a case report. J Spinal Cord Med, 44(4), 621–626. https://doi.org/10.1080/10790268.2019.1660841
Kahn, L. C., Evans, A. G., Hill, E. J. R., & Fox, I. K. (2022). Donor activation focused rehabilitation approach to hand closing nerve transfer surgery in individuals with cervical level spinal cord injury. Spinal Cord Ser Cases, 8(1), 47. https://doi.org/10.1038/s41394-022-00512-y
Bunketorp-Käll, L., Reinholdt, C., Fridén, J., & Wangdell, J. (2017). Essential gains and health after upper-limb tetraplegia surgery identified by the International classification of functioning, disability and health (ICF). Spinal Cord, 55(9), 857–863. https://doi.org/10.1038/sc.2017.36
Fox, I. K., Miller, A. K., & Curtin, C. M. (2018). Nerve and Tendon Transfer Surgery in Cervical Spinal Cord Injury: Individualized Choices to Optimize Function. Topics in Spinal Cord Injury Rehabilitation, 24(3), 275–287. https://doi.org/10.1310/sci2403-275
Dunn, J. A., Sinnott, K. A., Rothwell, A. G., Mohammed, K. D., & Simcock, J. W. (2016). Tendon Transfer Surgery for People With Tetraplegia: An Overview. Archives of Physical Medicine and Rehabilitation, 97(6), S75–S80. https://doi.org/10.1016/j.apmr.2016.01.034
Javeed, S., Dibble, C. F., Greenberg, J. K., Zhang, J. K., Khalifeh, J. M., Park, Y., Wilson, T. J., Zager, E. L., Faraji, A. H., Mahan, M. A., Yang, L. J., Midha, R., Juknis, N., & Ray, W. Z. (2022). Upper Limb Nerve Transfer Surgery in Patients With Tetraplegia. JAMA Netw Open, 5(11), e2243890-. https://doi.org/10.1001/jamanetworkopen.2022.43890
Evidence for “What are the risks of nerve transfers?” is based on:
Francoisse, C. A., Russo, S. A., Skladman, R., Kahn, L. C., Kennedy, C., Stenson, K. C., Novak, C. B., & Fox, I. K. (2022). Quantifying Donor Deficits Following Nerve Transfer Surgery in Tetraplegia. J Hand Surg Am, 47(12), 1157–1165. https://doi.org/10.1016/j.jhsa.2022.08.014
van Zyl, N., Hill, B., Cooper, C., Hahn, J., & Galea, M. P. (2019). Expanding traditional tendon-based techniques with nerve transfers for the restoration of upper limb function in tetraplegia: a prospective case series. Lancet, 394(10198), 565–575. https://doi.org/10.1016/S0140-6736(19)31143-2
Bertelli, J. A., & Ghizoni, M. F. (2017). Nerve transfers for restoration of finger flexion in patients with tetraplegia. Journal of Neurosurgery: Spine, 26(1), 55–61. https://doi.org/10.3171/2016.5.SPINE151544
Wilson, T. J. (2019). Novel Uses of Nerve Transfers. Neurotherapeutics, 16(1), 26–35. https://doi.org/10.1007/s13311-018-0664-x Khalifeh, J. M., Dibble, C. F., Van Voorhis, A., Doering, M., Boyer, M. I., Mahan, M. A., Wilson, T. J., Midha, R., Yang, L. J. S., & Ray, W. Z. (2019a). Nerve transfers in the upper extremity following cervical spinal cord injury. Part 1: Systematic review of the literature. Journal of Neurosurgery: Spine, 31(5), 629–640. https://doi.org/10.3171/2019.4.SPINE19173
Mooney, A., Hewitt, A. E., & Hahn, J. (2021). Nothing to lose: a phenomenological study of upper limb nerve transfer surgery for individuals with tetraplegia. Disabil Rehabil, 43(26), 3748–3756. https://doi.org/10.1080/09638288.2020.1750716
Hill, E. J. R., & Fox, I. K. (2019). Current Best Peripheral Nerve Transfers for Spinal Cord Injury. Plastic & Reconstructive Surgery, 143(1), 184e–198e. https://doi.org/10.1097/PRS.0000000000005173
Evidence for “What are the limitations of nerve transfers?” is based on:
Mooney, A., Hewitt, A. E., & Hahn, J. (2021). Nothing to lose: a phenomenological study of upper limb nerve transfer surgery for individuals with tetraplegia. Disabil Rehabil, 43(26), 3748–3756. https://doi.org/10.1080/09638288.2020.1750716
Hill, E. J. R., & Fox, I. K. (2019). Current Best Peripheral Nerve Transfers for Spinal Cord Injury. Plastic & Reconstructive Surgery, 143(1), 184e–198e. https://doi.org/10.1097/PRS.0000000000005173
Heredia Gutiérrez, A., Cachón Cámara, G. E., González Carranza, V., Torres García, S., & Chico Ponce de León, F. (2020). Phrenic nerve neurotization utilizing half of the spinal accessory nerve to the functional restoration of the paralyzed diaphragm in high spinal cord injury secondary to brain tumor resection. Child’s Nervous System, 36(6), 1307–1310. https://doi.org/10.1007/s00381-019-04490-9
Bazarek, S., & Brown, J. M. (2020). The evolution of nerve transfers for spinal cord injury. Experimental Neurology, 333, 113426. https://doi.org/10.1016/j.expneurol.2020.113426
Evidence for “Are nerve transfers effective?” is based on:
Javeed, S., Dibble, C. F., Greenberg, J. K., Zhang, J. K., Khalifeh, J. M., Park, Y., Wilson, T. J., Zager, E. L., Faraji, A. H., Mahan, M. A., Yang, L. J., Midha, R., Juknis, N., & Ray, W. Z. (2022). Upper Limb Nerve Transfer Surgery in Patients With Tetraplegia. JAMA Netw Open, 5(11), e2243890-. https://doi.org/10.1001/jamanetworkopen.2022.43890
Khalifeh, J. M., Dibble, C. F., Van Voorhis, A., Doering, M., Boyer, M. I., Mahan, M. A., Wilson, T. J., Midha, R., Yang, L. J. S., & Ray, W. Z. (2019b). Nerve transfers in the upper extremity following cervical spinal cord injury. Part 2: Preliminary results of a prospective clinical trial. Journal of Neurosurgery: Spine, 31(5). https://doi.org/10.3171/2019.4.SPINE19399
Stanley, E. A., Hill, B., McKenzie, D. P., Chapuis, P., Galea, M. P., & N, van Z. (2022). Predicting strength outcomes for upper limb nerve transfer surgery in tetraplegia. J Hand Surg Eur Vol, 47(11), 1114–1120. https://doi.org/10.1177/17531934221113739
van Zyl, N., Hill, B., Cooper, C., Hahn, J., & Galea, M. P. (2019). Expanding traditional tendon-based techniques with nerve transfers for the restoration of upper limb function in tetraplegia: a prospective case series. Lancet, 394(10198), 565–575. https://doi.org/10.1016/S0140-6736(19)31143-2
Image credits
- Nerve Transfer by SCIRE
- Elbow Extension by SCIRE
- Wrist Extension by SCIRE
- Finger Extension by SCIRE
- Finger Flexion and Pinch by SCIRE
- Nerve and Tendon Transfers to Improve Upper Limb Function in Cervical Spinal Cord Injury (video)
- Nerve Transfer Level of Injury by SCIRE
- Time Sensitive Nerve Transfers by SCIRE
- Nerve Transfer Timeline by SCIRE
- Tendon Transfer by SCIRE
- Photo provided by participant (Caleb)
- Photo provided by participant (Ainsley)
- Photo provided by participant (Dan)